Allogeneic bone grafting has recently been used in oral and maxillofacial regions to restore the cosmetic and functional problem. There are several types of allogeneic bone grafts ; bone powder, bone chips, bone blocks. Empirically, it is thought
to be
better to combine the allogeneic bone chips to any type of tissue adhesive not to displace during packing and condensing. But there are no reports about using tissue adhesive in allogeneic bone grafting
This experimental study is designed to investigate the effect of the fibrin adhesive on bone healing process after demineralized allogeneic bone grafting in 60 rats. In control groups (30 rats), routine demineralized allogeneic bone grafting were
done
in 7×7mm calvarial bone defects which were drilled intentioally. And we used the fibrin adhesive for holding the bone particle in experimental groups (30 rats).
Each experimental specimen was sacrified at 1, 2, 4, 6, 8 weeks postoperatively
@ES The results were as follows :
@EN 1. The degree of inflammatory cell infiltrations were more prominent in experimental than in control groups till 2 weeks.
2. Early fibroblast proliferation and new capillary proliferation were uncorporated around graft sites in the experimental groups later than in control groups at early stages.
3. Osteoblastic activity in control group was more prominent at 2 weeks.
4. Osteoclastic activity in experimental groups was more prominent than in control group till 4 weeks.
5. New bone formation was more in control group than experimental group till 3 weeks, but similar appearance after that time.
As above results, initial bone healing within 2 weeks were more processed in without adhesive group than with adhesive group. But above 4 weeks, similar bone healing were observed.
|